Antioxidant and Anti-Inflammatory Properties of Bee Products Potentially Reduce Oxidative Stress and Inflammation After Physical Activity/Exercise: A Systematic Review

Authors

DOI:

https://doi.org/10.17309/tmfv.2023.6.19

Keywords:

oxidative stress, Inflammation, Physical training, Healthy Lifestyle, bee products

Abstract

Study purpose. This research aims to analyze and highlight the potential of bee products in reducing oxidative stress and inflammation after physical activity/exercise.

Materials and methods. This research uses a systematic review method by searching various journal databases such as Scopus, Web of Science, PubMed and Embase. The inclusion criteria in this study were articles published in the last 5 years and articles discussing bee products, honey, oxidative stress, inflammation, physical activity, and exercise. The exclusion criteria in this study were articles published in disreputable journals. Titles, abstracts, and full texts of articles were screened then verified and stored in Mendeley software. A total of 7,124 articles from the Scopus, Web of Science, PubMed and Embase databases were identified. A total of 8 articles that met the inclusion criteria were selected and analyzed for this systematic review.

Results. Bee products that have anti-oxidant properties can reduce oxidative stress and the anti-inflammatory properties of bee products can reduce uncontrolled inflammation due to exercise.

Conclusions. Bee products contain flavonoids which have anti-oxidant properties which can reduce oxidative stress. In addition, the anti-inflammatory properties of bee products can reduce uncontrolled inflammation due to physical activity/exercise. In this case, honey works by inhibiting inflammation through NF-κB signals and reducing inflammation by suppressing the secretion of pro-inflammatory cytokines such as TNF-α and inflammatory markers such as CRP. Reducing inflammation can reduce the intensity of muscle pain. It is recommended that bee products be used in individuals to reduce oxidative stress and inflammation after physical activity/exercise. 

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Author Biographies

Donny Ardy Kusuma, Universitas Negeri Surabaya

Sport & Exercise Research Center, Department of Sport Coaching Education, Faculty of Sports and Health Sciences
Jl. Lidah Wetan, Lidah Wetan, Kec. Lakarsantri, Kota SBY, Jawa Timur 60213, Indonesia
donnykusuma@unesa.ac.id

Mohamed Nashrudin Bin Naharudin, Universiti Malaya

Faculty of Sports and Exercise Science
Kuala Lumpur, 50603, Federal Territory of Kuala Lumpur, Malaysia
nashrudin@um.edu.my

Cyuzuzo Callixte, University of Rwanda

P.O. Box 117, Butare, Rwanda
c.cyuzuzo@ur.ac.rw

Muhammad Aljunaid, University of Taiz

P.O. Box 6803, Taiz, Yemen
mohammed.aljunaid90@gmail.com

Awang Firmansyah, Universitas Negeri Surabaya

Faculty of Sport Science
Jl. Lidah Wetan, Lidah Wetan, Kec. Lakarsantri, Kota SBY, Jawa Timur 60213, Indonesia
awangfirmansyah@unesa.ac.id

Deby Tri Mario, Universitas Negeri Padang

Department of Sport Education, Faculty of Sport Science
Jl. Prof. Dr. Hamka No.1, Air Tawar Bar., Kec. Padang Utara, Kota Padang, Sumatera Barat 25173, Indonesia
debytrimario91@gmail.com

Ilham, Universitas Negeri Padang

Health and Recreation Department
Jl. Prof. Dr. Hamka No.1, Air Tawar Bar., Kec. Padang Utara, Kota Padang, Sumatera Barat 25173, Indonesia
ilhamf@fik.unp.ac.id

Anton Komaini, Universitas Negeri Padang

Faculty of Sport Science
Jl. Prof. Dr. Hamka No.1, Air Tawar Bar., Kec. Padang Utara, Kota Padang, Sumatera Barat 25173, Indonesia
antonkomaini@fik.unp.ac.id

Novadri Ayubi, Universitas Negeri Surabaya

Doctoral Program of Sport Science
Jl. Lidah Wetan, Lidah Wetan, Kec. Lakarsantri, Kota SBY, Jawa Timur 60213, Indonesia
novadriayubii@yahoo.com

References

Ruegsegger, G. N., & Booth, F. W. (2018). Health benefits of exercise. Cold Spring Harbor Perspectives in Medicine. https://doi.org/10.1101/cshperspect.a029694 DOI: https://doi.org/10.1101/cshperspect.a029694

Thirupathi, A., Wang, M., Lin, J. K., Fekete, G., István, B., Baker, J. S., & Gu, Y. (2021). Effect of Different Exercise Modalities on Oxidative Stress: A Systematic Review. BioMed Research International, 2021, 1-10. https://doi.org/10.1155/2021/1947928 DOI: https://doi.org/10.1155/2021/1947928

Darenskaya, M. A., Kolesnikova, L. I., & Kolesnikov, S. I. (2021). Oxidative Stress: Pathogenetic Role in Diabetes Mellitus and Its Complications and Therapeutic Approaches to Correction. Bulletin of Experimental Biology and Medicine, 171(2), 179-189. https://doi.org/10.1007/s10517-021-05191-7 DOI: https://doi.org/10.1007/s10517-021-05191-7

Harty, P. S., Cottet, M. L., Malloy, J. K., & Kerksick, C. M. (2019). Nutritional and Supplementation Strategies to Prevent and Attenuate Exercise-Induced Muscle Damage: a Brief Review. In Sports Medicine - Open. https://doi.org/10.1186/s40798-018-0176-6 DOI: https://doi.org/10.1186/s40798-018-0176-6

Casanova, N., Reis, J. F., Vaz, J. R., Machado, R., Mendes, B., Button, D. C., Pezarat-Correia, P., & Freitas, S. R. (2018). Effects of roller massager on muscle recovery after exercise-induced muscle damage. Journal of Sports Sciences. https://doi.org/10.1080/02640414.2017.1280609 DOI: https://doi.org/10.1080/02640414.2017.1280609

Owens, D. J., Twist, C., Cobley, J. N., Howatson, G., & Close, G. L. (2019). Exercise-induced muscle damage: What is it, what causes it and what are the nutritional solutions? In European Journal of Sport Science. https://doi.org/10.1080/17461391.2018.1505957 DOI: https://doi.org/10.1080/17461391.2018.1505957

Romero-Parra, N., Cupeiro, R., Alfaro-Magallanes, V. M., Rael, B., Rubio-Arias, J., Peinado, A. B., & Benito, P. J. (2021). Exercise-Induced Muscle Damage During the Menstrual Cycle: A Systematic Review and Meta-Analysis. Journal of Strength and Conditioning Research. https://doi.org/10.1519/JSC.0000000000003878 DOI: https://doi.org/10.1519/JSC.0000000000003878

Viribay, A., Arribalzaga, S., Mielgo-Ayuso, J., Castañeda-Babarro, A., Seco-Calvo, J., & Urdampilleta, A. (2020). Effects of 120 g/h of carbohydrates intake during a mountain marathon on exercise-induced muscle damage in elite runners. Nutrients. https://doi.org/10.3390/nu12051367 DOI: https://doi.org/10.3390/nu12051367

Xin, G., & Eshaghi, H. (2021). Effect of omega-3 fatty acids supplementation on indirect blood markers of exercise-induced muscle damage: Systematic review and meta-analysis of randomized controlled trials. In Food Science and Nutrition. https://doi.org/10.1002/fsn3.2598 DOI: https://doi.org/10.1002/fsn3.2598

Dupuy, O., Douzi, W., Theurot, D., Bosquet, L., & Dugué, B. (2018). An evidence-based approach for choosing post-exercise recovery techniques to reduce markers of muscle damage, Soreness, fatigue, and inflammation: A systematic review with meta-analysis. Frontiers in Physiology. https://doi.org/10.3389/fphys.2018.00403 DOI: https://doi.org/10.3389/fphys.2018.00403

Esteves-Lima, R. P., Reis, C. S., Santirocchi-Júnior, F., Abreu, L. G., & Costa, F. O. (2020). Association between periodontitis and serum c-reactive protein levels. Journal of Clinical and Experimental Dentistry. https://doi.org/10.4317/jced.57041 DOI: https://doi.org/10.4317/jced.57041

Oosthuyse, T., & Bosch, A. N. (2017). The effect of gender and menstrual phase on serum creatine kinase activity and muscle soreness following downhill running. Antioxidants. https://doi.org/10.3390/antiox6010016 DOI: https://doi.org/10.3390/antiox6010016

Chang, W. D., Lin, H. Y., Chang, N. J., & Wu, J. H. (2021). Effects of 830 nm Light-Emitting Diode Therapy on Delayed-Onset Muscle Soreness. Evidence-Based Complementary and Alternative Medicine. https://doi.org/10.1155/2021/6690572 DOI: https://doi.org/10.1155/2021/6690572

Hung, B. L., Sun, C. Y., Chang, N. J., & Chang, W. D. (2021). Effects of Different Kinesio-Taping Applications for Delayed Onset Muscle Soreness after High-Intensity Interval Training Exercise: A Randomized Controlled Trial. Evidence-Based Complementary and Alternative Medicine. https://doi.org/10.1155/2021/6676967 DOI: https://doi.org/10.1155/2021/6676967

Muljadi, J. A., Kaewphongsri, P., Chaijenkij, K., & Kongtharvonskul, J. (2021). Effect of caffeine on delayed-onset muscle soreness: a meta-analysis of RCT. Bulletin of the National Research Centre. https://doi.org/10.1186/s42269-021-00660-5 DOI: https://doi.org/10.1186/s42269-021-00660-5

Ayubi, N., & Sastika Putri, D. R. (2021). Aerobic Exercise and Omega 3 Supplementation to Reduce Primary Dysmenorrhea (Literature Review). Indian Journal of Forensic Medicine & Toxicology, 15(3 SE), 1413-1417. https://doi.org/10.37506/ijfmt.v15i3.15503 DOI: https://doi.org/10.37506/ijfmt.v15i3.15503

Kyriakidou, Y., Wood, C., Ferrier, C., Dolci, A., & Elliott, B. (2021). The effect of Omega-3 polyunsaturated fatty acid supplementation on exercise-induced muscle damage. Journal of the International Society of Sports Nutrition. https://doi.org/10.1186/s12970-020-00405-1 DOI: https://doi.org/10.1186/s12970-020-00405-1

Schoenfeld, B. J. (2012). The use of nonsteroidal anti-inflammatory drugs for exercise-induced muscle damage: Implications for skeletal muscle development. Sports Medicine, 42(12), 1017-1028. https://doi.org/10.2165/11635190-000000000-00000 DOI: https://doi.org/10.1007/BF03262309

Ali, A. M., & Kunugi, H. (2020). Apitherapy for Age-Related Skeletal Muscle Dysfunction (Sarcopenia): A Review on the Effects of Royal Jelly, Propolis, and Bee Pollen. In Foods, 9(10). https://doi.org/10.3390/foods9101362 DOI: https://doi.org/10.3390/foods9101362

Esa, N. E. F., Ansari, M. N. M., Razak, S. I. A., Ismail, N. I., Jusoh, N., Zawawi, N. A., Jamaludin, M. I., Sagadevan, S., & Nayan, N. H. M. (2022). A Review on Recent Progress of Stingless Bee Honey and Its Hydrogel-Based Compound for Wound Care Management. Molecules (Basel, Switzerland), 27(10). https://doi.org/10.3390/molecules27103080 DOI: https://doi.org/10.3390/molecules27103080

Eteraf-Oskouei, T., Shafiee-Khamneh, A., Heshmati-Afshar, F., & Delazar, A. (2020). Anti-inflammatory and anti-angiogenesis effect of bee pollen methanolic extract using air pouch model of inflammation. Research in Pharmaceutical Sciences, 15(1), 66-75. https://doi.org/10.4103/1735-5362.278716 DOI: https://doi.org/10.4103/1735-5362.278716

Srivastava, C., Gupta, Y., Irshad, K., Chattopadhaya, P., Sarkar, C., Suri, A., Sinha, S., & Chosdol, K. (2017). Curcumin downregulates FAT1 expression via NFkB in glioblastoma. Annals of Oncology. https://doi.org/10.1093/annonc/mdx657.005 DOI: https://doi.org/10.1093/annonc/mdx657.005

Cianciosi, D., Forbes-Hernández, T. Y., Afrin, S., Gasparrini, M., Reboredo-Rodriguez, P., Manna, P. P., Zhang, J., Bravo Lamas, L., Martínez Flórez, S., Agudo Toyos, P., Quiles, J. L., Giampieri, F., & Battino, M. (2018). Phenolic Compounds in Honey and Their Associated Health Benefits: A Review. Molecules (Basel, Switzerland), 23(9). https://doi.org/10.3390/molecules23092322 DOI: https://doi.org/10.3390/molecules23092322

Iova, G. M., Calniceanu, H., Popa, A., Szuhanek, C. A., Marcu, O., Ciavoi, G., & Scrobota, I. (2021). The antioxidant effect of curcumin and rutin on oxidative stress biomarkers in experimentally induced periodontitis in hyperglycemicwistar rats. Molecules. https://doi.org/10.3390/molecules26051332 DOI: https://doi.org/10.3390/molecules26051332

Kheirdeh, M., Koushkie Jahromi, M., Brühl, A. B., & Brand, S. (2022). The Effect of Exercise Training and Royal Jelly on Hippocampal Cannabinoid-1-Receptors and Pain Threshold in Experimental Autoimmune Encephalomyelitis in Rats as Animal Model of Multiple Sclerosis. Nutrients, 14(19). https://doi.org/10.3390/nu14194119 DOI: https://doi.org/10.3390/nu14194119

Petelin, A., Kenig, S., Kopinč, R., Deželak, M., Černelič Bizjak, M., & Jenko Pražnikar, Z. (2019). Effects of royal jelly administration on lipid profile, satiety, inflammation, and antioxidant capacity in asymptomatic overweight adults. Evidence-Based Complementary and Alternative Medicine, 2019. https://doi.org/10.1155/2019/4969720 DOI: https://doi.org/10.1155/2019/4969720

Ali, A. M., Ali, E. M., Mousa, A. A., Ahmed, M. E., & Hendawy, A. O. (2021). Bee honey and exercise for improving physical performance, reducing fatigue, and promoting an active lifestyle during COVID-19. Sports Medicine and Health Science, 3(3), 177-180. https://doi.org/10.1016/j.smhs.2021.06.002 DOI: https://doi.org/10.1016/j.smhs.2021.06.002

Ranneh, Y., Mahmoud, A. M., Fadel, A., Albujja, M., Akim, A. M., Hamid, H. A., & Khazaai, H. (2021). Acute Inflammation and Oxidative Stress Induced by Lipopolysaccharide and the Ameliorative Effect of Stingless Bee Honey. Combinatorial Chemistry & High Throughput Screening, 24(6), 744-757. https://doi.org/10.2174/1386207323999200918152111 DOI: https://doi.org/10.2174/1386207323999200918152111

Tavafzadeh, S. S., Chen, C. K., Ooi, F. K., Hamzah, N. A., Sulaiman, S. A., & Osman, J. M. (2023). Effects of Aerobic Dance Exercise and Honey Supplementation Followed by Their Subsequent Cessation on Bone Metabolism Markers and Antioxidant Status in Young Collegiate Females. The Malaysian Journal of Medical Sciences : MJMS, 30(3), 151-166. https://doi.org/10.21315/mjms2023.30.3.14 DOI: https://doi.org/10.21315/mjms2023.30.3.14

Stavropoulou, E., Ieronymaki, E., Dimitroulia, E., Constantinidis, T. C., Vrioni, G., Tsatsanis, C., & Tsakris, A. (2022). Anti-Inflammatory and Antibacterial Effects and Mode of Action of Greek Arbutus, Chestnut, and Fir Honey in Mouse Models of Inflammation and Sepsis. Microorganisms, 10(12). https://doi.org/10.3390/microorganisms10122374 DOI: https://doi.org/10.3390/microorganisms10122374

Ovchinnikov, A. N., Paoli, A., Seleznev, V. V, & Deryugina, A. V. (2022). Royal jelly plus coenzyme Q10 supplementation improves high-intensity interval exercise performance via changes in plasmatic and salivary biomarkers of oxidative stress and muscle damage in swimmers: a randomized, double-blind, placebo-controlled pilot t. Journal of the International Society of Sports Nutrition, 19(1), 239-257. https://doi.org/10.1080/15502783.2022.2086015 DOI: https://doi.org/10.1080/15502783.2022.2086015

Noura, M., Arshadi, S., Zafari, A., & Banaeyfar, A. (n.d.). Effect of Endurance Training with Royal Jelly on CRP Gene Expression in Muscle Tissue of Rats with Alzheimer ’s Disease. Middle East Journal of Rehabilitation and Health Studies, 7(1), e99754. https://doi.org/10.5812/mejrh.99754 DOI: https://doi.org/10.5812/mejrh.99754

Silva, B., Biluca, F. C., Gonzaga, L. V., Fett, R., Dalmarco, E. M., Caon, T., & Costa, A. C. O. (2021). In vitro anti-inflammatory properties of honey flavonoids: A review. Food Research International, 141, 110086. https://doi.org/https://doi.org/10.1016/j.foodres.2020.110086 DOI: https://doi.org/10.1016/j.foodres.2020.110086

Wang, F., Wang, X., Liu, Y., & Zhang, Z. (2021). Effects of Exercise-Induced ROS on the Pathophysiological Functions of Skeletal Muscle. In Oxidative Medicine and Cellular Longevity. https://doi.org/10.1155/2021/3846122 DOI: https://doi.org/10.1155/2021/3846122

Eddaikra, A., & Eddaikra, N. (2021). Endogenous Enzymatic Antioxidant Defense and Pathologies (V. Waisundara (ed.); p. Ch. 26). IntechOpen. https://doi.org/10.5772/intechopen.95504 DOI: https://doi.org/10.5772/intechopen.95504

Simioni, C., Zauli, G., Martelli, A. M., Vitale, M., Sacchetti, G., Gonelli, A., & Neri, L. M. (2018). Oxidative stress: role of physical exercise and antioxidant nutraceuticals in adulthood and aging. Oncotarget, 9(24), 17181-17198. https://doi.org/10.18632/oncotarget.24729 DOI: https://doi.org/10.18632/oncotarget.24729

Hajam, Y. A., Rani, R., Ganie, S. Y., Sheikh, T. A., Javaid, D., Qadri, S. S., Pramodh, S., Alsulimani, A., Alkhanani, M. F., Harakeh, S., Hussain, A., Haque, S., & Reshi, M. S. (2022). Oxidative Stress in Human Pathology and Aging: Molecular Mechanisms and Perspectives. Cells, 11(3). https://doi.org/10.3390/cells11030552 DOI: https://doi.org/10.3390/cells11030552

Overdevest, E., Wouters, J. A., Wolfs, K. H. M., van Leeuwen, J. J. M., & Possemiers, S. (2018). Citrus Flavonoid Supplementation Improves Exercise Performance in Trained Athletes. Journal of Sports Science & Medicine, 17(1), 24-30.

Marshall, J. S., Warrington, R., Watson, W., & Kim, H. L. (2018). An introduction to immunology and immunopathology. Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology, 14(Suppl 2), 49. https://doi.org/10.1186/s13223-018-0278-1 DOI: https://doi.org/10.1186/s13223-018-0278-1

Ayubi, N., Purwanto Bambang, Rejeki, P. S., Kusnanik, N. W., & Herawati, L. (2022). Effect of acute omega 3 supplementation reduces serum tumor necrosis factor-alpha (TNF-a) levels, pain intensity, and maintains muscle strength after high-intensity weight training. Retos, 46, 677-682. DOI: https://doi.org/10.47197/retos.v46.93720

Fernández-Lázaro, D., Mielgo-Ayuso, J., Calvo, J. S., Martínez, A. C., García, A. C., & Fernandez-Lazaro, C. I. (2020). Modulation of exercise-induced muscle damage, inflammation, and oxidative markers by curcumin supplementation in a physically active population: A systematic review. In Nutrients. https://doi.org/10.3390/nu12020501 DOI: https://doi.org/10.3390/nu12020501

Nanavati, K., Rutherfurd-Markwick, K., Lee, S. J., Bishop, N. C., & Ali, A. (2022). Effect of curcumin supplementation on exercise-induced muscle damage: a narrative review. European Journal of Nutrition. https://doi.org/10.1007/s00394-022-02943-7 DOI: https://doi.org/10.1007/s00394-022-02943-7

Acar, L., Atalan, N., Karagedik, E. H., & Ergen, A. (2018). Tumour Necrosis Factor-alpha and Nuclear Factor-kappa B Gene Variants in Sepsis. Balkan Medical Journal, 35(1), 30-35. https://doi.org/10.4274/balkanmedj.2017.0246 DOI: https://doi.org/10.4274/balkanmedj.2017.0246

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Published

2023-12-22

How to Cite

Kusuma, D. A., Naharudin, M. N. B., Callixte, C., Aljunaid, M., Firmansyah, A., Mario, D. T., Ilham, Komaini, A., & Ayubi, N. (2023). Antioxidant and Anti-Inflammatory Properties of Bee Products Potentially Reduce Oxidative Stress and Inflammation After Physical Activity/Exercise: A Systematic Review. Physical Education Theory and Methodology, 23(6), 954–962. https://doi.org/10.17309/tmfv.2023.6.19

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